3TZA

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Glutamate receptor 2,Glutamate receptor 2	polymer	263	29221.7	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	A, B	(S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid	non-polymer		316.7	2	Chemie (TZG)
3	A, B	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4		water	water		18.0	632	Chemie (HOH)

Sequence modifications

A, B: 0 - 114 (UniProt: P19491)

PDB	External Database	Details
Gly -2	-	expression tag
Ala -1	-	expression tag

A, B: 117 - 260 (UniProt: P19491)

PDB	External Database	Details
Gly 115	-	linker
Thr 116	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58443.4
Non-Polymers*	Number of molecules	6
	Total formula weight	1017.6
All*	Total formula weight	59461.0

*Water molecules are not included.