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3TU1

Exhaustive Fluorine Scanning towards Potent p53-MDM2 Antagonist

Summary for 3TU1
Entry DOI10.2210/pdb3tu1/pdb
DescriptorE3 ubiquitin-protein ligase Mdm2, 3-[(1S)-2-(tert-butylamino)-1-{N-[(3,4-difluorophenyl)methyl]formamido}-2-oxoethyl]-6-chloro-1H-indole-2-carboxylic acid (3 entities in total)
Functional Keywordsp53-binding protein mdm2, oncoprotein mdm2, double minute 2 protein, hdm2, oncoprotein, p53, nucleus, ligase
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains1
Total formula weight12926.16
Authors
Wolf, S.,Huang, Y.,Koes, D.,Popowicz, G.M.,Camacho, C.J.,Holak, T.A.,Doemling, A. (deposition date: 2011-09-15, release date: 2011-11-02, Last modification date: 2024-05-29)
Primary citationHuang, Y.,Wolf, S.,Koes, D.,Popowicz, G.M.,Camacho, C.J.,Holak, T.A.,Domling, A.
Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists.
Chemmedchem, 7:49-52, 2012
Cited by
PubMed: 21954050
DOI: 10.1002/cmdc.201100428
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.603 Å)
Structure validation

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