3TU1
Exhaustive Fluorine Scanning towards Potent p53-MDM2 Antagonist
Summary for 3TU1
Entry DOI | 10.2210/pdb3tu1/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, 3-[(1S)-2-(tert-butylamino)-1-{N-[(3,4-difluorophenyl)methyl]formamido}-2-oxoethyl]-6-chloro-1H-indole-2-carboxylic acid (3 entities in total) |
Functional Keywords | p53-binding protein mdm2, oncoprotein mdm2, double minute 2 protein, hdm2, oncoprotein, p53, nucleus, ligase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 1 |
Total formula weight | 12926.16 |
Authors | Wolf, S.,Huang, Y.,Koes, D.,Popowicz, G.M.,Camacho, C.J.,Holak, T.A.,Doemling, A. (deposition date: 2011-09-15, release date: 2011-11-02, Last modification date: 2024-05-29) |
Primary citation | Huang, Y.,Wolf, S.,Koes, D.,Popowicz, G.M.,Camacho, C.J.,Holak, T.A.,Domling, A. Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists. Chemmedchem, 7:49-52, 2012 Cited by PubMed: 21954050DOI: 10.1002/cmdc.201100428 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.603 Å) |
Structure validation
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