3T5F

Human Thrombin In Complex With MI340

Summary for 3T5F

• Entry DOI: 10.2210/pdb3t5f/pdb
• Related: 3RLW 3RLY 3RM0 3RM2 3RML 3RMM
• Related PRD ID: PRD_000801
• Descriptor: Thrombin Light Chain, Thrombin Heavy Chain, Hirudin variant-2, ... (9 entities in total)
• Functional Keywords: serine protease, kringle, hydrolase, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, cleavage on pairs of basic residues, hirudin, glycosylation, blood, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 36712.97

Authors

Biela, A.,Heine, A.,Klebe, G. (deposition date: 2011-07-27, release date: 2012-08-01, Last modification date: 2023-12-06)

• Primary citation: Biela, A.,Sielaff, F.,Terwesten, F.,Heine, A.,Steinmetzer, T.,Klebe, G.; Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect; J.Med.Chem., 55:6094-6110, 2012; PubMed: 22612268; DOI: 10.1021/jm300337q

Experimental method

X-RAY DIFFRACTION (1.45 Å)