3SI3

Human Thrombin In Complex With UBTHR103

Summary for 3SI3

Entry DOI	10.2210/pdb3si3/pdb
Related	3P17 3QTO 3QTV 3QWC 3QX5 3RLW
Related PRD ID	PRD_000790
Descriptor	Thrombin light chain, Thrombin heavy chain, Hirudin variant-2, ... (9 entities in total)
Functional Keywords	serine protease, kringle, hydrolase, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, cleavage on pairs of basic residues, blood clotting inhibitor, thrombin inhibitor, glycosylation, blood, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	36346.12
Authors	Biela, A.,Heine, A.,Klebe, G. (deposition date: 2011-06-17, release date: 2012-06-20, Last modification date: 2023-12-06)
Primary citation	Biela, A.,Khayat, M.,Tan, H.,Kong, J.,Heine, A.,Hangauer, D.,Klebe, G. Impact of ligand and protein desolvation on ligand binding to the S1 pocket of thrombin J.Mol.Biol., 418:350-366, 2012 Cited by PubMed: 22366545 DOI: 10.1016/j.jmb.2012.01.054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation