3RYW
Crystal structure of P. vivax geranylgeranyl diphosphate synthase complexed with BPH-811
Summary for 3RYW
Entry DOI | 10.2210/pdb3ryw/pdb |
Related | 3CC9 3RBM |
Descriptor | Farnesyl pyrophosphate synthase, {2-[5-(decyloxy)pyridin-3-yl]ethane-1,1-diyl}bis(phosphonic acid), MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | transferase, geranylgeranyl diphosphate synthase, bph-811 |
Biological source | Plasmodium vivax |
Total number of polymer chains | 4 |
Total formula weight | 187232.42 |
Authors | No, J.H.,Liu, Y.-L.,Zhang, Y.,Oldfield, E. (deposition date: 2011-05-11, release date: 2012-05-23, Last modification date: 2023-09-13) |
Primary citation | No, J.H.,de Macedo Dossin, F.,Zhang, Y.,Liu, Y.L.,Zhu, W.,Feng, X.,Yoo, J.A.,Lee, E.,Wang, K.,Hui, R.,Freitas-Junior, L.H.,Oldfield, E. Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc.Natl.Acad.Sci.USA, 109:4058-4063, 2012 Cited by PubMed: 22392982DOI: 10.1073/pnas.1118215109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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