3QIP
Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine
Summary for 3QIP
Entry DOI | 10.2210/pdb3qip/pdb |
Descriptor | Reverse HIV-1 reverse transcriptase p66, p51, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, ... (8 entities in total) |
Functional Keywords | hiv, reverse transcriptase, rnase h, polymerase, nuclease, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | HIV-1 M:B_HXB2R (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116962.55 |
Authors | Lansdon, E.B.,Kirschberg, T.A. (deposition date: 2011-01-27, release date: 2011-04-20, Last modification date: 2023-09-13) |
Primary citation | Lansdon, E.B.,Liu, Q.,Leavitt, S.A.,Balakrishnan, M.,Perry, J.K.,Lancaster-Moyer, C.,Kutty, N.,Liu, X.,Squires, N.H.,Watkins, W.J.,Kirschberg, T.A. Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55:2905-2915, 2011 Cited by PubMed: 21464257DOI: 10.1128/AAC.01594-10 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.0926 Å) |
Structure validation
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