3NZI

Substrate induced remodeling of the active site regulates HtrA1 activity

Summary for 3NZI

• Entry DOI: 10.2210/pdb3nzi/pdb
• Related: 3NUM 3NWU
• Descriptor: Serine protease HTRA1, Citrate synthase (2 entities in total)
• Functional Keywords: serine protease, degp, htra, protease, hydrolase-peptide inhibitor complex, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane : Q92743
• Total number of polymer chains: 2
• Total formula weight: 37535.77

Authors

Truebestein, L.,Tennstaedt, A.,Hauske, P.,Krojer, T.,Kaiser, M.,Clausen, T.,Ehrmann, M. (deposition date: 2010-07-16, release date: 2011-02-23, Last modification date: 2023-11-22)

• Primary citation: Truebestein, L.,Tennstaedt, A.,Monig, T.,Krojer, T.,Canellas, F.,Kaiser, M.,Clausen, T.,Ehrmann, M.; Substrate-induced remodeling of the active site regulates human HTRA1 activity.; Nat.Struct.Mol.Biol., 18:386-388, 2011; PubMed: 21297635; DOI: 10.1038/nsmb.2013

Experimental method

X-RAY DIFFRACTION (2.75 Å)