3NZI

Substrate induced remodeling of the active site regulates HtrA1 activity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serine protease HTRA1	polymer	334	36685.9	1	UniProt (Q92743) Pfam (PF13365) Pfam (PF17820)	Homo sapiens (human)	L56, Serine protease 11
2	B (B)	Citrate synthase	polymer	7	849.9	1	UniProt (Q80X68) UniProt (by SIFTS) (Q9CZU6)

Sequence modifications

A: 158 - 480 (UniProt: Q92743)

PDB	External Database	Details
Met 157	-	expression tag
Arg 481	-	expression tag
Ser 482	-	expression tag
Leu 483	-	expression tag
Glu 484	-	expression tag
His 485	-	expression tag
His 486	-	expression tag
His 487	-	expression tag
His 488	-	expression tag
His 489	-	expression tag
His 490	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	37535.8
All*	Total formula weight	37535.8

*Water molecules are not included.