3NZI

Substrate induced remodeling of the active site regulates HtrA1 activity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR CHAIN B OF CITRATE SYNTHASE

Chain	Residue
A	HIS220
A	LYS346
A	LEU309
A	ASN324
A	TYR325
A	GLY326
A	ASN327
A	SER328
A	THR344
A	LEU345

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337

Chain	Residue	Details
B	LYS6
A	ASP250
A	SER328

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Involved in trimer stabilization => ECO:0000269|PubMed:21297635

Chain	Residue	Details
A	TYR169
A	PHE171
A	PHE278

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