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3KZ1

Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA

Summary for 3KZ1
Entry DOI10.2210/pdb3kz1/pdb
Related1A2B 1TXD 1X86 1XCG
DescriptorRho guanine nucleotide exchange factor 11, Transforming protein RhoA, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsregulation of rhoa gtpase, rhogef, dh, ph, rho, gtpase activation, guanine-nucleotide releasing factor, membrane, cytoskeleton, gtp-binding, magnesium, nucleotide-binding, prenylation, proto-oncogene, signaling protein
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: O15085
Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
Total number of polymer chains4
Total formula weight131312.79
Authors
Chen, Z.,Sternweis, P.C.,Sprang, S.R. (deposition date: 2009-12-07, release date: 2010-04-28, Last modification date: 2023-09-06)
Primary citationChen, Z.,Medina, F.,Liu, M.Y.,Thomas, C.,Sprang, S.R.,Sternweis, P.C.
Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.
J.Biol.Chem., 285:21070-21081, 2010
Cited by
PubMed: 20430886
DOI: 10.1074/jbc.M110.122549
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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