3KLS

Structure of complement C5 in complex with SSL7

Summary for 3KLS

Entry DOI	10.2210/pdb3kls/pdb
Related	2QEJ 3CU7 3KM9
Descriptor	Complement C5, Exotoxin 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	ob-fold, b-grasp domain, fn3 domain, cleavage on pair of basic residues, complement alternate pathway, complement pathway, cytolysis, disulfide bond, glycoprotein, immune response, inflammatory response, innate immunity, membrane attack complex, secreted, immune system
Biological source	Staphylococcus aureus subsp. aureus More
Total number of polymer chains	4
Total formula weight	431383.93
Authors	Laursen, N.S.,Gordon, N.,Hermans, S.,Lorenz, N.,Jackson, N.,Wines, B.,Spillner, E.,Christensen, J.B.,Jensen, M.,Fredslund, F.,Bjerre, M.,Sottrup-Jensen, L.,Fraser, J.D.,Andersen, G.R. (deposition date: 2009-11-09, release date: 2009-11-24, Last modification date: 2023-11-01)
Primary citation	Laursen, N.S.,Gordon, N.,Hermans, S.,Lorenz, N.,Jackson, N.,Wines, B.,Spillner, E.,Christensen, J.B.,Jensen, M.,Fredslund, F.,Bjerre, M.,Sottrup-Jensen, L.,Fraser, J.D.,Andersen, G.R. Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus Proc.Natl.Acad.Sci.USA, 107:3681-3686, 2010 Cited by PubMed: 20133685 DOI: 10.1073/pnas.0910565107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.6 Å)

Structure validation