3KD5

Closed ternary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair and phosphonoformic acid.

Summary for 3KD5

• Entry DOI: 10.2210/pdb3kd5/pdb
• Related: 3KD1
• Descriptor: DNA (5'-D(*CP*GP*TP*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(4DG))-3'), DNA polymerase, ... (6 entities in total)
• Functional Keywords: polymerase, gp43, human cytomegalovirus, hcmv, acyclic guanosine, acyclovir, phosphonoformic acid, foscarnet, foscavir, antiviral, dna replication, dna-binding, dna-directed dna polymerase, exonuclease, hydrolase, nuclease, nucleotidyltransferase, transferase, transferase-dna complex, transferase/dna
• Biological source: Enterobacteria phage RB69 (Bacteriophage RB69); More
• Total number of polymer chains: 3
• Total formula weight: 115776.61

Authors

Zahn, K.E.,Doublie, S. (deposition date: 2009-10-22, release date: 2011-04-13, Last modification date: 2023-09-06)

• Primary citation: Zahn, K.E.,Tchesnokov, E.P.,Gotte, M.,Doublie, S.; Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase.; J.Biol.Chem., 286:25246-25255, 2011; PubMed: 21566148; DOI: 10.1074/jbc.M111.248864

Experimental method

X-RAY DIFFRACTION (2.69 Å)