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3ITH

Crystal structure of the HIV-1 reverse transcriptase bound to a 6-vinylpyrimidine inhibitor

Summary for 3ITH
Entry DOI10.2210/pdb3ith/pdb
Related3ISN
DescriptorReverse transcriptase/ribonuclease H, p51 RT, 6-ethenyl-N,N-dimethyl-2-(methylsulfonyl)pyrimidin-4-amine (3 entities in total)
Functional Keywordshiv-1, inhibitor, rt, transferase, hydrolase
Biological sourceHuman immunodeficiency virus (HIV-1)
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
Total number of polymer chains4
Total formula weight229341.50
Authors
Freisz, S.,Bec, G.,Wolff, P.,Dumas, P.,Radi, M.,Botta, M. (deposition date: 2009-08-28, release date: 2010-03-16, Last modification date: 2023-11-01)
Primary citationFreisz, S.,Bec, G.,Radi, M.,Wolff, P.,Crespan, E.,Angeli, L.,Dumas, P.,Maga, G.,Botta, M.,Ennifar, E.
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action
Angew.Chem.Int.Ed.Engl., 49:1805-1808, 2010
Cited by
PubMed: 20135654
DOI: 10.1002/anie.200905651
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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