3I80

Protein Tyrosine Phosphatase 1B - Transition state analog for the second catalytic step

Summary for 3I80

Entry DOI	10.2210/pdb3i80/pdb
Related	1A5Y 1PTU 2CM2 2HNQ 3I7Z
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
Functional Keywords	hydrolase, p-loop, wpd-loop, protein phosphatase, vanadate, acetylation, endoplasmic reticulum, membrane, oxidation, phosphoprotein, polymorphism
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	37879.00
Authors	Brandao, T.A.S.,Johnson, S.J.,Hengge, A.C. (deposition date: 2009-07-09, release date: 2010-03-16, Last modification date: 2023-09-06)
Primary citation	Brandao, T.A.,Hengge, A.C.,Johnson, S.J. Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285:15874-15883, 2010 Cited by PubMed: 20236928 DOI: 10.1074/jbc.M109.066951 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation