3I7Z

Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step

Summary for 3I7Z

Entry DOI	10.2210/pdb3i7z/pdb
Related	1A5Y 1PTU 2CM2 2HNQ 3I80
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, EGFR receptor fragment, VANADATE ION, ... (6 entities in total)
Functional Keywords	hydrolase, p-loop, wpd-loop, protein phosphatase, egfr receptor, vanadate, acetylation, endoplasmic reticulum, membrane, oxidation, phosphoprotein, polymorphism
Biological source	Homo sapiens (human) More
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	2
Total formula weight	38633.76
Authors	Brandao, T.A.S.,Johnson, S.J.,Hengge, A.C. (deposition date: 2009-07-09, release date: 2010-03-16, Last modification date: 2023-09-06)
Primary citation	Brandao, T.A.,Hengge, A.C.,Johnson, S.J. Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285:15874-15883, 2010 Cited by PubMed: 20236928 DOI: 10.1074/jbc.M109.066951 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation