3HY4
Structure of human MTHFS with N5-iminium phosphate
Summary for 3HY4
Entry DOI | 10.2210/pdb3hy4/pdb |
Related | 3HXT 3HY3 3HY6 |
Descriptor | 5-formyltetrahydrofolate cyclo-ligase, NICKEL (II) ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | antifolate, cancer, n5-iminium phosphate, acetylation, atp-binding, cytoplasm, folate-binding, ligase, magnesium, nucleotide-binding, polymorphism |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P49914 |
Total number of polymer chains | 1 |
Total formula weight | 24083.80 |
Authors | |
Primary citation | Wu, D.,Li, Y.,Song, G.,Cheng, C.,Zhang, R.,Joachimiak, A.,Shaw, N.,Liu, Z.-J. Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69:7294-7301, 2009 Cited by PubMed: 19738041DOI: 10.1158/0008-5472.CAN-09-1927 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.795 Å) |
Structure validation
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