3HPG

Visna virus integrase (residues 1-219) in complex with LEDGF IBD: examples of open integrase dimer-dimer interfaces

Summary for 3HPG

Entry DOI	10.2210/pdb3hpg/pdb
Related	1K6Y 2B4J 3F9K 3HPH
Descriptor	Integrase, PC4 and SFRS1-interacting protein, ZINC ION (3 entities in total)
Functional Keywords	protein-protein complex, tetramer, dna integration, endonuclease, magnesium, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, zinc, dna-binding, host-virus interaction, transcription, transcription regulation, zinc binding, hhcc motif, viral protein, recombination
Biological source	Maedi visna virus (MVV) More
Cellular location	Nucleus: O75475
Total number of polymer chains	12
Total formula weight	217391.00
Authors	Hare, S.,Labeja, A.,Cherepanov, P. (deposition date: 2009-06-04, release date: 2009-07-28, Last modification date: 2023-11-01)
Primary citation	Hare, S.,Di Nunzio, F.,Labeja, A.,Wang, J.,Engelman, A.,Cherepanov, P. Structural basis for functional tetramerization of lentiviral integrase Plos Pathog., 5:e1000515-e1000515, 2009 Cited by PubMed: 19609359 DOI: 10.1371/journal.ppat.1000515 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.28 Å)

Structure validation