3HPG

Visna virus integrase (residues 1-219) in complex with LEDGF IBD: examples of open integrase dimer-dimer interfaces

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Integrase	polymer	219	25090.5	6	UniProt (P35956) Pfam (PF02022) Pfam (PF00665) In PDB	Maedi visna virus (MVV)	IN
2	G, H, I, J, K...	PC4 and SFRS1-interacting protein	polymer	95	11076.0	6	UniProt (O75475) Pfam (PF11467) In PDB	Homo sapiens (human)	Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52, Dense fine speckles 70 kDa protein, DFS 70, CLL-associated antigen KW-7
3	A, B, C, D, E...	ZINC ION	non-polymer		65.4	6	Chemie (ZN)

Sequence modifications

A, B, C, D, E, F: 3 - 219 (UniProt: P35956)

PDB	External Database	Details
Met 1	-	expression tag
Val 2	-	expression tag

G, H, I, J, K, L: 347 - 435 (UniProt: O75475)

PDB	External Database	Details
Leu 436	-	expression tag
Glu 437	-	expression tag
Val 438	-	expression tag
Leu 439	-	expression tag
Phe 440	-	expression tag
Gln 441	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	216998.5
Non-Polymers*	Number of molecules	6
	Total formula weight	392.5
All*	Total formula weight	217391.0

*Water molecules are not included.