3H5B

Crystal structure of wild type HIV-1 protease with novel P1'-ligand GRL-02031

Summary for 3H5B

Entry DOI	10.2210/pdb3h5b/pdb
Related	2HB3 2IEN 2Z4O 3DJK 3DK1
Descriptor	HIV-1 protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	hiv-1, wild type protease, protease inhibitor, p1'-ligand, aids, hydrolase
Biological source	Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1)
Cellular location	Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains	2
Total formula weight	22269.06
Authors	Tie, Y.,Wang, Y.F.,Weber, I.T. (deposition date: 2009-04-21, release date: 2009-06-16, Last modification date: 2023-09-06)
Primary citation	Ghosh, A.K.,Leshchenko-Yashchuk, S.,Anderson, D.D.,Baldridge, A.,Noetzel, M.,Miller, H.B.,Tie, Y.,Wang, Y.F.,Koh, Y.,Weber, I.T.,Mitsuya, H. Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies. J.Med.Chem., 52:3902-3914, 2009 Cited by PubMed: 19473017 DOI: 10.1021/jm900303m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.29 Å)

Structure validation