3GIS
Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin
Summary for 3GIS
Entry DOI | 10.2210/pdb3gis/pdb |
Descriptor | Prothrombin, Thrombomodulin, SULFATE ION, ... (6 entities in total) |
Functional Keywords | protein-protein complex, coagulation, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, zymogen, egf-like domain, hydroxylation, membrane, receptor, thrombophilia, transmembrane, blood clotting |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Membrane; Single-pass type I membrane protein: P07204 |
Total number of polymer chains | 9 |
Total formula weight | 146571.21 |
Authors | Adams, T.E.,Huntington, J.A. (deposition date: 2009-03-06, release date: 2009-08-18, Last modification date: 2023-11-01) |
Primary citation | Adams, T.E.,Li, W.,Huntington, J.A. Molecular basis of thrombomodulin activation of slow thrombin J.Thromb.Haemost., 7:1688-1695, 2009 Cited by PubMed: 19656282DOI: 10.1111/j.1538-7836.2009.03563.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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