3GIS
Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Prothrombin | polymer | 49 | 5641.2 | 3 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
| 2 | B, D, F (B, D, F) | Prothrombin | polymer | 259 | 29764.2 | 3 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
| 3 | G, H, I (X, Y, Z) | Thrombomodulin | polymer | 121 | 12931.3 | 3 | UniProt (P07204) Pfam (PF12662) | Homo sapiens (human) | TM, Fetomodulin |
| 4 | J, K, L, M, N... (A, B, C, D, E...) | SULFATE ION | non-polymer | 96.1 | 15 | Chemie (SO4) | |||
| 5 | AA, Y, Z (Z, X, Y) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 6 | BA, CA, DA, EA, FA... (A, B, C, D, E...) | water | water | 18.0 | 575 | Chemie (HOH) |
Sequence modifications
B, D, F: 16 - 247 (UniProt: P00734)
X, Y, Z: 345 - 465 (UniProt: P07204)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 388 | Met 406 | engineered mutation |
| Gly 456 | Arg 474 | engineered mutation |
| Gln 457 | His 475 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 145010.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1561.2 | |
| All* | Total formula weight | 146571.2 |
