3E94

Crystal structure of RXRalpha ligand binding domain in complex with tributyltin and a coactivator fragment

Summary for 3E94

• Entry DOI: 10.2210/pdb3e94/pdb
• Related: 1LBD 1XDK 2P1T 2P1U 2P1V
• Descriptor: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2 peptide, tributylstannanyl, ... (5 entities in total)
• Functional Keywords: protein-ligand complex, dna-binding, host-virus interaction, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger, activator, phosphoprotein
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P19793 Q15596
• Total number of polymer chains: 2
• Total formula weight: 29198.48

Authors

Bourguet, W.,Le Maire, A. (deposition date: 2008-08-21, release date: 2009-03-10, Last modification date: 2023-08-30)

• Primary citation: le Maire, A.,Grimaldi, M.,Roecklin, D.,Dagnino, S.,Vivat-Hannah, V.,Balaguer, P.,Bourguet, W.; Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors; Embo Rep., 10:367-373, 2009; PubMed: 19270714; DOI: 10.1038/embor.2009.8

Experimental method

X-RAY DIFFRACTION (1.9 Å)