3D44

Crystal structure of HePTP in complex with a dually phosphorylated Erk2 peptide mimetic

Summary for 3D44

Entry DOI	10.2210/pdb3d44/pdb
Related	1zc0 2gp0 2hvl 2qdc 2qdm 2qdp 3d42
Descriptor	Tyrosine-protein phosphatase non-receptor type 7, Mitogen-activated protein kinase 1 peptide, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	heptp, human hematopoietic tyrosine phosphatase catalytic domain mutant, lc-ptp, ptpn7, erk2, ptp-peptide complex, mapk-derived peptide, hydrolase, phosphoprotein, protein phosphatase
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm: P35236 Nucleus: P28482
Total number of polymer chains	2
Total formula weight	36448.20
Authors	Critton, D.A.,Tortajada, A.,Page, R. (deposition date: 2008-05-13, release date: 2009-03-17, Last modification date: 2023-11-15)
Primary citation	Critton, D.A.,Tortajada, A.,Stetson, G.,Peti, W.,Page, R. Structural basis of substrate recognition by hematopoietic tyrosine phosphatase. Biochemistry, 47:13336-13345, 2008 Cited by PubMed: 19053285 DOI: 10.1021/bi801724n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation