3D44
Crystal structure of HePTP in complex with a dually phosphorylated Erk2 peptide mimetic
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 2 |
| Chain | Residue |
| A | TYR137 |
| A | GLN288 |
| A | HOH345 |
| A | HOH469 |
| A | HOH476 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 3 |
| Chain | Residue |
| A | THR62 |
| A | SER242 |
| A | ALA243 |
| A | HIS324 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 4 |
| Chain | Residue |
| A | TRP64 |
| A | ARG68 |
| A | ARG135 |
| A | LEU307 |
| A | HOH608 |
| A | HOH609 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1 |
| Chain | Residue |
| A | LYS140 |
| A | GLU141 |
| A | LYS142 |
| A | PRO263 |
| A | GLY264 |
| A | PRO265 |
| A | HOH362 |
| A | HOH507 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by MAP2K1 and MAP2K2 => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | ASP183 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by MAP2K1 and MAP2K2 => ECO:0000269|PubMed:19053285, ECO:0000269|PubMed:19494114, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | PTR185 | |
| A | SER270 | |
| A | GLN314 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:19060905 |
| Chain | Residue | Details |
| B | THR188 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:10206983 |
| Chain | Residue | Details |
| A | SER72 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER89 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER122 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000250 |
| Chain | Residue | Details |
| A | SER270 |
