3BBR
Crystal structure of the iGluR2 ligand binding core (S1S2J-N775S) in complex with a dimeric positive modulator as well as glutamate at 2.25 A resolution
Summary for 3BBR
Entry DOI | 10.2210/pdb3bbr/pdb |
Related | 1LBC 2AL4 2AL5 |
Descriptor | Glutamate receptor 2, SULFATE ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | ampa receptor, glur2, s1s2, ligand binding core, point mutation, n775s, dimeric positive modulator, agonist, cell junction, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphorylation, postsynaptic cell membrane, rna editing, synapse, transmembrane, transport, membrane protein |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 2 |
Total formula weight | 59808.11 |
Authors | Kastrup, J.S.,Gajhede, M. (deposition date: 2007-11-11, release date: 2007-12-04, Last modification date: 2023-11-01) |
Primary citation | Kaae, B.H.,Harpsoe, K.,Kastrup, J.S.,Sanz, A.C.,Pickering, D.S.,Metzler, B.,Clausen, R.P.,Gajhede, M.,Sauerberg, P.,Liljefors, T.,Madsen, U. Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites Chem.Biol., 14:1294-1303, 2007 Cited by PubMed: 18022568DOI: 10.1016/j.chembiol.2007.10.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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