3AY4

Crystal structure of nonfucosylated Fc complexed with bis-glycosylated soluble form of Fc gamma receptor IIIa

Summary for 3AY4

• Entry DOI: 10.2210/pdb3ay4/pdb
• Related: 1E4K 1T83 1T89 2DTS 3AVE
• Descriptor: Ig gamma-1 chain C region, Low affinity immunoglobulin gamma Fc region receptor III-A, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: immune system, complex, fc fragment, igg, receptor, cd16, gamma
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 75844.47

Authors

Mizushima, T.,Takemoto, E.,Yagi, H.,Shibata-Koyama, M.,Isoda, Y.,Iida, S.,Satoh, M.,Kato, K. (deposition date: 2011-04-28, release date: 2011-08-03, Last modification date: 2023-11-01)

• Primary citation: Mizushima, T.,Yagi, H.,Takemoto, E.,Shibata-Koyama, M.,Isoda, Y.,Iida, S.,Masuda, K.,Satoh, M.,Kato, K.; Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans; Genes Cells, 16:1071-1080, 2011; PubMed: 22023369; DOI: 10.1111/j.1365-2443.2011.01552.x

Experimental method

X-RAY DIFFRACTION (2.2 Å)