37LU

NPC1-NPC2 complex with bis-sterol molecule JM046, pH 5.5

Summary for 37LU

• Entry DOI: 10.2210/pdb37lu/pdb
• EMDB information: 78289
• Descriptor: NPC intracellular cholesterol transporter 1, NPC intracellular cholesterol transporter 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: transporter, complex, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 164976.39

Authors

Wu, X.,Yan, N. (deposition date: 2026-07-25, release date: 2026-09-30)

• Primary citation: Wu, X.,Dehghani-Ghahnaviyeh, S.,Rasouli, A.,Malona, J.,Antalek, M.,Jones, L.H.,Fan, X.,Peng, A.,Tajkhorshid, E.,Qian, H.,Yan, N.; Conformation switch of NPC1 epitomizes a lumen-to-membrane alternating access for nonpolar substrates; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.2 Å)