37IR

Crystal structure of Interferon alpha8 bound to IFA003 ScFv

Summary for 37IR

• Entry DOI: 10.2210/pdb37ir/pdb
• Related: 11LZ 37II
• EMDB information: 78204
• Descriptor: Interferon alpha-8, IFA003 variable heavy chain ScFv, IFA003 variable light chain ScFv, ... (4 entities in total)
• Functional Keywords: ifn, antibody-antigen complex, autoantibody, autoimmunity, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 51023.52

Authors

Vasquez, S.,Rubio, A.A.,Barnes, C.O. (deposition date: 2026-07-22, release date: 2026-11-04)

• Primary citation: Groen, K.,Moritz, J.A.,Vasquez, S.,Rubio, A.A.,Kuratli, R.,Jones, D.,Grafl, D.,Motta, M.,Fontana, S.,Manning, J.,Costagli, S.,Simonelli, L.,Thakur, R.,Jarrossay, D.,Tran, C.,Lee, Y.E.,Abela, I.A.,Calmy, A.,Hirzel, C.,Kaufmann, D.E.,Gunthard, H.F.,Kouyos, R.D.,Barnes, C.O.,Robbiani, D.F.,Hale, B.G.; Developmental and molecular features shaping broad and synergistic actions of human autoantibodies targeting interferon-alpha; Biorxiv, 2026; DOI: 10.64898/2026.10.20.760426

Experimental method

X-RAY DIFFRACTION (2.08 Å)