37IR

Crystal structure of Interferon alpha8 bound to IFA003 ScFv

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interferon alpha-8	polymer	206	23907.9	1	UniProt (P32881)	Homo sapiens (human)	IFN-alpha-8,Interferon alpha-B,LeIF B,Interferon alpha-B2
2	B (H)	IFA003 variable heavy chain ScFv	polymer	138	14410.7	1		Homo sapiens
3	C (L)	IFA003 variable light chain ScFv	polymer	118	12704.9	1		Homo sapiens
4	D, E, F (A, H, L)	water	water		18.0	233	Chemie (HOH)

Sequence modifications

A: 1 - 166 (UniProt: P32881)

PDB	External Database	Details
Glu 167	-	expression tag
Asn 168	-	expression tag
Leu 169	-	expression tag
Tyr 170	-	expression tag
Phe 171	-	expression tag
Gln 172	-	expression tag
Gly 173	-	expression tag
Gly 174	-	expression tag
Gly 175	-	expression tag
Gly 176	-	expression tag
Gly 177	-	expression tag
Ser 178	-	expression tag
Gly 179	-	expression tag
Gly 180	-	expression tag
Gly 181	-	expression tag
Gly 182	-	expression tag
Ser 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
His 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
Gly 192	-	expression tag
Leu 193	-	expression tag
Asn 194	-	expression tag
Asp 195	-	expression tag
Ile 196	-	expression tag
Phe 197	-	expression tag
Glu 198	-	expression tag
Ala 199	-	expression tag
Gln 200	-	expression tag
Lys 201	-	expression tag
Ile 202	-	expression tag
Glu 203	-	expression tag
Trp 204	-	expression tag
His 205	-	expression tag
Glu 206	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	51023.5
All*	Total formula weight	51023.5

*Water molecules are not included.