11LZ

Crystal structure of Interferon alpha2 bound to IFA001 Fab

Summary for 11LZ

• Entry DOI: 10.2210/pdb11lz/pdb
• Descriptor: Interferon alpha-2, IFA001 Fab light chain, IFA001 Fab heavy chain, ... (4 entities in total)
• Functional Keywords: ifn, complex, autoantibody, autoimmunity, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 140387.91

Authors

Vasquez, S.,Rubio, A.A.,Barnes, C.O. (deposition date: 2026-03-04, release date: 2026-11-04)

• Primary citation: Groen, K.,Moritz, J.A.,Vasquez, S.,Rubio, A.A.,Kuratli, R.,Jones, D.,Grafl, D.,Motta, M.,Fontana, S.,Manning, J.,Costagli, S.,Simonelli, L.,Thakur, R.,Jarrossay, D.,Tran, C.,Lee, Y.E.,Abela, I.A.,Calmy, A.,Hirzel, C.,Kaufmann, D.E.,Swiss HIV Cohort Study,Gunthard, H.F.,Kouyos, R.D.,Barnes, C.O.,Robbiani, D.F.,Hale, B.G.; Developmental and molecular features shaping broad and synergistic actions of human autoantibodies targeting IFN alpha; Biorxiv, 2026; DOI: 10.64898/2026.10.20.760426

Experimental method

X-RAY DIFFRACTION (2.8 Å)