34CY

Homo sapiens Eukaryotic translation initiation factor 4E (eIF4E) in complex with synthetic mRNA cap analogs

This is a non-PDB format compatible entry.

Summary for 34CY

• Entry DOI: 10.2210/pdb34cy/pdb
• Related: 34AK 34CO 34CV
• Descriptor: Eukaryotic translation initiation factor 4E, [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-2-[[[[[(1~{R},3~{R},4~{R},7~{S})-3-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-yl)-7-oxidanyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-4-methylsulfanyl-oxolan-3-yl] (2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)methyl hydrogen phosphate (3 entities in total)
• Functional Keywords: cap complex, rna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 94068.65

Authors

Schneider, S.,Schwarz, A. (deposition date: 2026-09-08, release date: 2026-10-14)

• Primary citation: Schneider, S.,Moreno, S.,Thran, M.,Schwarz, A.; Structural basis of eIF4E recognition of synthetic mRNA 5′ cap analogues links cap architecture to affinity and biological activity; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)