34CO

Homo sapiens Eukaryotic translation initiation factor 4E (eIF4E) in complex with synthetic mRNA cap analogs

This is a non-PDB format compatible entry.

Summary for 34CO

• Entry DOI: 10.2210/pdb34co/pdb
• Related: 34AK
• Descriptor: Eukaryotic translation initiation factor 4E, [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-2-[[[[2-[2-(2-azanyl-7-methyl-6-oxidanylidene-3~{H}-purin-9-yl)ethoxy]ethoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-4-methoxy-oxolan-3-yl] [5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (3 entities in total)
• Functional Keywords: complex, rna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 94188.66

Authors

Schneider, S.,Schwarz, A. (deposition date: 2026-09-08, release date: 2026-10-21)

• Primary citation: Schneider, S.,Moreno, S.,Thran, M.,Schwarz, A.; Structural basis of eIF4E recognition of synthetic mRNA cap analogues links cap architecture to affinity and biological activity; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)