32JC

Structure of the pathogenic variant T186R of Human SHMT2 in a distorted tetrameric conformation

Summary for 32JC

• Entry DOI: 10.2210/pdb32jc/pdb
• Related: 32JA
• Descriptor: Serine hydroxymethyltransferase, mitochondrial (1 entity in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 107730.37

Authors

Giardina, G.,Boumis, G.,Di Matteo, A.,Breccia, S. (deposition date: 2026-07-11, release date: 2026-09-02)

• Primary citation: Giardina, G.,Boumis, G.,Di Matteo, A.,Breccia, S.; Structural and functional defects of mitochondrial serine hydroxymethyltransferase genetic variants responsible for a novel neurodevelopmental syndrome; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.07 Å)