2ZNQ
Human PPAR delta ligand binding domain in complex with a synthetic agonist TIPP401
Summary for 2ZNQ
Entry DOI | 10.2210/pdb2znq/pdb |
Related | 2ZNN 2ZNO 2ZNP |
Descriptor | Peroxisome proliferator-activated receptor delta, heptyl beta-D-glucopyranoside, (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptor, protein-ligand complex, ppar, activator, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q03181 |
Total number of polymer chains | 2 |
Total formula weight | 64466.76 |
Authors | Oyama, T.,Hirakawa, Y.,Nagasawa, N.,Miyachi, H.,Morikawa, K. (deposition date: 2008-04-30, release date: 2009-05-05, Last modification date: 2023-11-01) |
Primary citation | Oyama, T.,Toyota, K.,Waku, T.,Hirakawa, Y.,Nagasawa, N.,Kasuga, J.,Hashimoto, Y.,Miyachi, H.,Morikawa, K. Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures Acta Crystallogr.,Sect.D, 65:786-795, 2009 Cited by PubMed: 19622862DOI: 10.1107/S0907444909015935 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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