2ZC9

Thrombin in complex with Inhibitor

Summary for 2ZC9
Related1H8D 1YPG 2ZDA 2ZDV
Related PRD IDPRD_000593
DescriptorThrombin Light Chain, Thrombin Heavy Chain, Hirudin variant-1, ... (6 entities in total)
Functional Keywordsblood clotting/serine protease inhibitors, secreted, sulfation, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, zymogen, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P01050
Total number of polymer chains3
Total formula weight35729.07
Authors
Baum, B.,Heine, A.,Klebe, G. (deposition date: 2007-11-06, release date: 2008-10-28, Last modification date: 2017-10-11)
Primary citationBaum, B.,Hangauer, D.,Heine, A.,Klebe, G.,Muley, L.,Smolinski, M.
Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin
J.Mol.Biol., 391:552-564, 2009
PubMed: 19520086
DOI: 110.1016/j.jmb.2009.06.016
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.58 Å)
Structure validation
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PDB entries from 2021-06-23