2ZC3

Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae

2ZC3 の概要

• エントリーDOI: 10.2210/pdb2zc3/pdb
• 関連するPDBエントリー: 2ZC4 2ZC5 2ZC6
• 分子名称: Penicillin-binding protein 2X, (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-meth yl-4,5-dihydro-1H-pyrrole-2-carboxylate, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: peptidoglycan synthesis, cell wall, penicillin-binding, antibiotics, biapenem, antibiotic resistance, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, membrane, secreted, transmembrane, biosynthetic protein
• 由来する生物種: Streptococcus pneumoniae; 詳細
• 細胞内の位置: Cell membrane; Single-pass membrane protein: P59676 P59676 P59676
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 149162.95

構造登録者

Yamada, M.,Watanabe, T.,Takeuchi, Y. (登録日: 2007-11-02, 公開日: 2008-04-08, 最終更新日: 2023-11-01)

• 主引用文献: Yamada, M.,Watanabe, T.,Baba, N.,Takeuchi, Y.,Ohsawa, F.,Gomi, S.; Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae; Antimicrob.Agents Chemother., 52:2053-2060, 2008; PubMed: 18391040; DOI: 10.1128/AAC.01456-07

実験手法

X-RAY DIFFRACTION (2.5 Å)