2Z8C

Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid

2Z8C の概要

• エントリーDOI: 10.2210/pdb2z8c/pdb
• 関連するPDBエントリー: 2Z7L
• 分子名称: Insulin receptor, 6-mer peptide from Insulin receptor substrate 1, [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID (3 entities in total)
• 機能のキーワード: transferase, alternative splicing, atp-binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphorylation, polymorphism, receptor, transmembrane, tyrosine-protein kinase, transducer
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P06213
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35826.57

構造登録者

Katayama, N.,Kurihara, H. (登録日: 2007-09-05, 公開日: 2008-08-12, 最終更新日: 2023-11-15)

• 主引用文献: Katayama, N.,Orita, M.,Yamaguchi, T.,Hisamichi, H.,Kuromitsu, S.,Kurihara, H.,Sakashita, H.,Matsumoto, Y.,Fujita, S.,Niimi, T.; Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors.; Proteins, 73:795-801, 2008; PubMed: 18767165; DOI: 10.1002/prot.22207

実験手法

X-RAY DIFFRACTION (3.25 Å)