2Z0P
Crystal structure of PH domain of Bruton's tyrosine kinase
Summary for 2Z0P
Entry DOI | 10.2210/pdb2z0p/pdb |
Descriptor | Tyrosine-protein kinase BTK, ZINC ION, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, ... (4 entities in total) |
Functional Keywords | ph domain, pip3c4, atp-binding, disease mutation, kinase, membrane, metal-binding, nucleotide-binding, nucleus, phosphorylation, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, zinc-finger, signaling protein, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q06187 |
Total number of polymer chains | 4 |
Total formula weight | 83059.09 |
Authors | Murayama, K.,Kato-Murayama, M.,Mishima, C.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-05-07, release date: 2008-05-13, Last modification date: 2023-11-01) |
Primary citation | Murayama, K.,Kato-Murayama, M.,Mishima, C.,Akasaka, R.,Shirouzu, M.,Fukui, Y.,Yokoyama, S. Crystal structure of the Bruton's tyrosine kinase PH domain with phosphatidylinositol Biochem.Biophys.Res.Commun., 377:23-28, 2008 Cited by PubMed: 18809383DOI: 10.1016/j.bbrc.2008.09.055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.58 Å) |
Structure validation
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