2YPA

Structure of the SCL:E47:LMO2:LDB1 complex bound to DNA

Summary for 2YPA

Entry DOI	10.2210/pdb2ypa/pdb
Related	1HLH 2XJY 2XJZ 2YPB
Descriptor	T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1, TRANSCRIPTION FACTOR E2-ALPHA, RHOMBOTIN-2, ... (7 entities in total)
Functional Keywords	immune system, hematopoiesis, leukemia
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Nucleus (By similarity): P17542 Nucleus: P15923 Nucleus (Potential): P25791 Nucleus (Probable): Q86U70
Total number of polymer chains	6
Total formula weight	49615.56
Authors	El Omari, K.,Hoosdally, S.J.,Tuladhar, K.,Karia, D.,Ponsele, E.,Platonova, O.,Vyas, P.,Patient, R.,Porcher, C.,Mancini, E.J. (deposition date: 2012-10-30, release date: 2013-07-31)
Primary citation	El Omari, K.,Hoosdally, S.J.,Tuladhar, K.,Karia, D.,Hall-Ponsele, E.,Platonova, O.,Vyas, P.,Patient, R.,Porcher, C.,Mancini, E.J. Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets. Cell Rep., 4:135-, 2013 Cited by PubMed: 23831025 DOI: 10.1016/J.CELREP.2013.06.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation