2YOL
West Nile Virus NS2B-NS3 protease in complex with 3,4- dichlorophenylacetyl-Lys-Lys-GCMA
Summary for 2YOL
Entry DOI | 10.2210/pdb2yol/pdb |
Descriptor | SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3, CHLORIDE ION, (S)-6-amino-N-((S)-6-amino-1-(((1r,4S)-4-guanidinocyclohexyl)methylamino)-1-oxohexan-2-yl)-2-(2-(3,4-dichlorophenyl)acetamido)hexanamide, ... (5 entities in total) |
Functional Keywords | serine protease, hydrolase, inhibitor |
Biological source | WEST NILE VIRUS |
Cellular location | Capsid protein C: Virion (Potential). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P06935 |
Total number of polymer chains | 1 |
Total formula weight | 25310.15 |
Authors | Hammamy, M.Z.,Haase, C.,Hammami, M.,Hilgenfeld, R.,Steinmetzer, T. (deposition date: 2012-10-25, release date: 2013-03-27, Last modification date: 2023-12-20) |
Primary citation | Hammamy, M.Z.,Haase, C.,Hammami, M.,Hilgenfeld, R.,Steinmetzer, T. Development and Characterization of New Peptidomimetic Inhibitors of the West Nile Virus Ns2B-Ns3 Protease. Chemmedchem, 8:231-, 2013 Cited by PubMed: 23307694DOI: 10.1002/CMDC.201200497 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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