2YOL

West Nile Virus NS2B-NS3 protease in complex with 3,4- dichlorophenylacetyl-Lys-Lys-GCMA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005524	molecular_function	ATP binding
A	0044423	cellular_component	virion component

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE EBN A 2170

Chain	Residue
A	TRP53
A	SER1135
A	TYR1150
A	GLY1151
A	ASN1152
A	GLY1153
A	ILE1155
A	TYR1161
A	GLU55
A	GLY83
A	PHE85
A	HIS1051
A	ASP1075
A	ASP1129
A	TYR1130
A	THR1132

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 2069

Chain	Residue
A	ILE60
A	THR1020

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NI A 2171

Chain	Residue
A	HIS1087
A	HIS1092

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860

Chain	Residue	Details
A	HIS1051
A	ASP1075
A	SER1135

---