2YCR

Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976

2YCR の概要

• エントリーDOI: 10.2210/pdb2ycr/pdb
• 関連するPDBエントリー: 1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XM8 2XM9 2YCF 2YCQ 2YCS
• 分子名称: SERINE/THREONINE-PROTEIN KINASE CHK2, 1,3-BIS{4-[(1E)-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)ETHANEHYDRAZONOYL]PHENYL}UREA, NITRATE ION, ... (4 entities in total)
• 機能のキーワード: transferase, anticancer drug design
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37100.80

構造登録者

Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Pommier, Y.,Shoemaker, R.H.,Zhang, G.,Waugh, D.S. (登録日: 2011-03-16, 公開日: 2011-11-16, 最終更新日: 2023-12-20)

• 主引用文献: Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Zhang, G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S.; Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.; J.Struct.Biol., 176:292-, 2011; PubMed: 21963792; DOI: 10.1016/J.JSB.2011.09.008

実験手法

X-RAY DIFFRACTION (2.2 Å)