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2YBT

Crystal structure of human acidic chitinase in complex with bisdionin C

Summary for 2YBT
Entry DOI10.2210/pdb2ybt/pdb
Related2YBU
DescriptorACIDIC MAMMALIAN CHITINASE, GLYCEROL, 1,1'-PROPANE-1,3-DIYLBIS(3,7-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE), ... (4 entities in total)
Functional Keywordshydrolase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: Q9BZP6
Total number of polymer chains6
Total formula weight261116.99
Authors
Sutherland, T.E.,Andersen, O.A.,Betou, M.,Eggleston, I.M.,Maizels, R.M.,van Aalten, D.,Allen, J.E. (deposition date: 2011-03-10, release date: 2011-06-08, Last modification date: 2023-12-20)
Primary citationSutherland, T.E.,Andersen, O.A.,Betou, M.,Eggleston, I.M.,Maizels, R.M.,van Aalten, D.,Allen, J.E.
Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.
Chem. Biol., 18:569-579, 2011
Cited by
PubMed: 21609838
DOI: 10.1016/j.chembiol.2011.02.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.22 Å)
Structure validation

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