2YBT

Crystal structure of human acidic chitinase in complex with bisdionin C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process
A	0008061	molecular_function	chitin binding
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0005975	biological_process	carbohydrate metabolic process
B	0008061	molecular_function	chitin binding
C	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
C	0005975	biological_process	carbohydrate metabolic process
C	0008061	molecular_function	chitin binding
D	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
D	0005975	biological_process	carbohydrate metabolic process
D	0008061	molecular_function	chitin binding
E	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
E	0005975	biological_process	carbohydrate metabolic process
E	0008061	molecular_function	chitin binding
F	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
F	0005975	biological_process	carbohydrate metabolic process
F	0008061	molecular_function	chitin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1398

Chain	Residue
A	TRP31
A	ARG35
A	GLU297
A	TRP360
A	DW01399
A	HOH2190
A	HOH2201

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 1398

Chain	Residue
B	GLU297
B	TRP360
B	DW01399
B	HOH2185
B	TRP31
B	ARG35

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 1398

Chain	Residue
C	TRP31
C	ARG35
C	GLU297
C	TRP360
C	DW01399
C	HOH2006
C	HOH2194

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 1398

Chain	Residue
D	TRP31
D	ARG35
D	GLU297
D	TRP360
D	DW01399
D	HOH2145

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 1398

Chain	Residue
E	TRP31
E	ARG35
E	TRP360
E	DW01399
E	HOH2128
E	HOH2186

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL F 1398

Chain	Residue
F	TRP31
F	ARG35
F	GLU297
F	ILE300
F	TRP360
F	DW01399
F	HOH2118

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE DW0 A 1399

Chain	Residue
A	TRP31
A	PHE58
A	GLY98
A	TRP99
A	ASN100
A	ASP138
A	GLU140
A	MET210
A	TYR212
A	TYR267
A	TRP360
A	GOL1398
A	HOH2052
A	HOH2119

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DW0 B 1399

Chain	Residue
B	TRP31
B	PHE58
B	GLY98
B	TRP99
B	ASN100
B	ASP138
B	GLU140
B	MET210
B	TYR212
B	TYR267
B	TRP360
B	GOL1398
B	HOH2193

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE DW0 C 1399

Chain	Residue
C	TRP31
C	PHE58
C	GLY98
C	TRP99
C	ASN100
C	ASP138
C	GLU140
C	MET210
C	TYR212
C	TYR267
C	TRP360
C	GOL1398
C	HOH2040
C	HOH2195

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE DW0 D 1399

Chain	Residue
D	TRP31
D	PHE58
D	GLY98
D	TRP99
D	ASN100
D	ASP138
D	GLU140
D	MET210
D	TYR212
D	TYR267
D	TRP360
D	GOL1398
D	HOH2037
D	HOH2146

---

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE DW0 E 1399

Chain	Residue
E	ASP138
E	GLU140
E	MET210
E	TYR212
E	TYR267
E	GLU297
E	TRP360
E	GOL1398
E	HOH2080
E	TRP31
E	PHE58
E	GLY98
E	TRP99
E	ASN100

---

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DW0 F 1399

Chain	Residue
F	TRP31
F	PHE58
F	GLY98
F	TRP99
F	ASN100
F	ASP138
F	GLU140
F	MET210
F	TYR212
F	TYR267
F	TRP360
F	GOL1398
F	HOH2132

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DW0 A 1400

Chain	Residue
A	TRP99
A	TRP218
A	HOH2202
D	GLN62

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DW0 B 1400

Chain	Residue
B	TRP99
B	TRP218
F	GLN62

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DW0 C 1400

Chain	Residue
C	TRP99
C	ASP213
C	TRP218
C	HOH2196
C	HOH2197

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DW0 D 1400

Chain	Residue
A	GLN62
D	TRP99
D	TRP218

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DW0 E 1400

Chain	Residue
E	TRP99
E	TRP218
E	HOH2187

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DW0 F 1400

Chain	Residue
B	GLN62
F	TRP99
F	TRP218

---

Functional Information from PROSITE/UniProt

site_id	PS01095
Number of Residues	9
Details	GH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. FDGLDFDwE

Chain	Residue	Details
A	PHE132-GLU140

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2208
Details	Domain: {"description":"GH18","evidences":[{"source":"PROSITE-ProRule","id":"PRU01258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	54
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---