2YBU
Crystal structure of human acidic chitinase in complex with bisdionin F
Summary for 2YBU
Entry DOI | 10.2210/pdb2ybu/pdb |
Related | 2YBT |
Descriptor | ACIDIC MAMMALIAN CHITINASE, GLYCEROL, 3,7-DIMETHYL-1-[3-(3-METHYL-2,6-DIOXO-9H-PURIN-1-YL)PROPYL]PURINE-2,6-DIONE, ... (4 entities in total) |
Functional Keywords | hydrolase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: Q9BZP6 |
Total number of polymer chains | 6 |
Total formula weight | 260948.67 |
Authors | Sutherland, T.E.,Andersen, O.A.,Betou, M.,Eggleston, I.M.,Maizels, R.M.,van Aalten, D.,Allen, J.E. (deposition date: 2011-03-10, release date: 2011-06-08, Last modification date: 2023-12-20) |
Primary citation | Sutherland, T.E.,Andersen, O.A.,Betou, M.,Eggleston, I.M.,Maizels, R.M.,van Aalten, D.,Allen, J.E. Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor. Chem. Biol., 18:569-579, 2011 Cited by PubMed: 21609838DOI: 10.1016/j.chembiol.2011.02.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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