2YB9
Crystal Structure of Human Neutral Endopeptidase complexed with a heteroarylalanine diacid.
Summary for 2YB9
Entry DOI | 10.2210/pdb2yb9/pdb |
Related | 1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J |
Descriptor | NEPRILYSIN, ZINC ION, HETEROARYLALANINE 5-PHENYL OXAZOLE, ... (4 entities in total) |
Functional Keywords | hydrolase, neprilysine, metalloproteinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type II membrane protein: P08473 |
Total number of polymer chains | 1 |
Total formula weight | 80033.42 |
Authors | Glossop, M.S.,Bazin, R.J.,Dack, K.N.,Done, S.,Fox, D.N.A.,MacDonald, G.A.,Mills, M.,Owen, D.R.,Phillips, C.,Reeves, K.A.,Ringer, T.J.,Strang, R.S.,Watson, C.A.L. (deposition date: 2011-03-02, release date: 2011-05-25, Last modification date: 2011-11-02) |
Primary citation | Glossop, M.S.,Bazin, R.J.,Dack, K.N.,Fox, D.N.A.,Macdonald, G.A.,Mills, M.,Owen, D.R.,Phillips, C.,Reeves, K.A.,Ringer, T.J.,Strang, R.S.,Watson, C.A.L. Synthesis and Evaluation of Heteroarylalanine Diacids as Potent and Selective Neutral Endopeptidase Inhibitors. Bioorg.Med.Chem.Lett., 21:3404-, 2011 Cited by PubMed: 21515054DOI: 10.1016/J.BMCL.2011.03.109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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