2YAU
X-ray structure of the Leishmania infantum tryopanothione reductase in complex with auranofin
Summary for 2YAU
Entry DOI | 10.2210/pdb2yau/pdb |
Related | 2JK6 2W0H 2X50 |
Descriptor | TRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | LEISHMANIA INFANTUM |
Total number of polymer chains | 2 |
Total formula weight | 114962.74 |
Authors | Baiocco, P.,Ilari, A.,Colotti, G. (deposition date: 2011-02-24, release date: 2012-01-11, Last modification date: 2023-12-20) |
Primary citation | Ilari, A.,Baiocco, P.,Messori, L.,Fiorillo, A.,Boffi, A.,Gramiccia, M.,Di Muccio, T.,Colotti, G. A Gold-Containing Drug Against Parasitic Polyamine Metabolism: The X-Ray Structure of Trypanothione Reductase from Leishmania Infantum in Complex with Auranofin Reveals a Dual Mechanism of Enzyme Inhibition. Amino Acids, 42:803-, 2012 Cited by PubMed: 21833767DOI: 10.1007/S00726-011-0997-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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