2YAU

X-ray structure of the Leishmania infantum tryopanothione reductase in complex with auranofin

2YAU の概要

• エントリーDOI: 10.2210/pdb2yau/pdb
• 関連するPDBエントリー: 2JK6 2W0H 2X50
• 分子名称: TRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: LEISHMANIA INFANTUM
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114962.74

構造登録者

Baiocco, P.,Ilari, A.,Colotti, G. (登録日: 2011-02-24, 公開日: 2012-01-11, 最終更新日: 2023-12-20)

• 主引用文献: Ilari, A.,Baiocco, P.,Messori, L.,Fiorillo, A.,Boffi, A.,Gramiccia, M.,Di Muccio, T.,Colotti, G.; A Gold-Containing Drug Against Parasitic Polyamine Metabolism: The X-Ray Structure of Trypanothione Reductase from Leishmania Infantum in Complex with Auranofin Reveals a Dual Mechanism of Enzyme Inhibition.; Amino Acids, 42:803-, 2012; PubMed: 21833767; DOI: 10.1007/S00726-011-0997-9

実験手法

X-RAY DIFFRACTION (3.5 Å)