2Y88

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PHOSPHORIBOSYL ISOMERASE (VARIANT D11N) WITH BOUND PRFAR

Summary for 2Y88

Entry DOI	10.2210/pdb2y88/pdb
Related	2Y85 2Y89
Descriptor	PHOSPHORIBOSYL ISOMERASE A, [(2R,3S,4R,5R)-5-[4-AMINOCARBONYL-5-[[(Z)-[(3R,4R)-3,4-DIHYDROXY-2-OXO-5-PHOSPHONOOXY-PENTYL]IMINOMETHYL]AMINO]IMIDAZOL-1-YL]-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL DIHYDROGEN PHOSPHATE (3 entities in total)
Functional Keywords	aromatic amino acid biosynthesis, isomerase, tim-barrel, histidine biosynthesis, tryptophan biosynthesis
Biological source	MYCOBACTERIUM TUBERCULOSIS
Total number of polymer chains	1
Total formula weight	26235.11
Authors	Kuper, J.,Due, A.V.,Geerlof, A.,Wilmanns, M. (deposition date: 2011-02-03, release date: 2011-03-02, Last modification date: 2023-12-20)
Primary citation	Due, A.V.,Kuper, J.,Geerlof, A.,Kries, J.P.,Wilmanns, M. Bisubstrate Specificity in Histidine/Tryptophan Biosynthesis Isomerase from Mycobacterium Tuberculosis by Active Site Metamorphosis. Proc.Natl.Acad.Sci.USA, 108:3554-, 2011 Cited by PubMed: 21321225 DOI: 10.1073/PNAS.1015996108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.33 Å)

Structure validation