2Y6O
Crystal structure of EphA4 kinase domain in complex with Dasatinib.
Summary for 2Y6O
Entry DOI | 10.2210/pdb2y6o/pdb |
Related | 1B0X 2XYU 2Y6M |
Descriptor | EPHRIN TYPE-A RECEPTOR 4, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total) |
Functional Keywords | signalling protein, transferase |
Biological source | MUS MUSCULUS (HOUSE MOUSE) |
Cellular location | Cell membrane; Single-pass type I membrane protein: Q03137 |
Total number of polymer chains | 1 |
Total formula weight | 33419.08 |
Authors | Farenc, C.J.A.,Celie, P.H.N.,Siegal, G. (deposition date: 2011-01-25, release date: 2011-11-02, Last modification date: 2023-12-20) |
Primary citation | Farenc, C.J.A.,Hameetman, L.,Zoutman, W.,Tensen, C.P.,Siegal, G. Crystal Structure of the Epha4 Protein Tyrosine Kinase Domain in the Apo- and Dasatinib-Bound State. FEBS Lett., 585:3593-, 2011 Cited by PubMed: 22036717DOI: 10.1016/J.FEBSLET.2011.10.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.543 Å) |
Structure validation
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